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Index > Protein center > Gulo(Gene name) > Rat
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  • Gulo (Gene name),
  • L-gulonolactone oxidase (Protein name ),  GGLO_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Gulo;
    Protein name:
    L-gulonolactone oxidase(LGO);
    Alternative:
    L-gulono-gamma-lactone oxidase(GLO);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.
    Subcellular Location:
    Microsome membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    440
    Sequence:
    50:
    MVHGYKGVQF | QNWAKTYGCS | PEVYYQPTSV | EEVREVLALA | REQKKKVKVV | 
    100:
    GGGHSPSDIA | CTDGFMIHMG | KMNRVLQVDK | EKKQITVEAG | ILLADLHPQL | 
    150:
    DEHGLAMSNL | GAVSDVTVAG | VIGSGTHNTG | IKHGILATQV | VALTLMTADG | 
    200:
    EVLECSESRN | ADVFQAARVH | LGCLGIILTV | TLQCVPQFHL | QETSFPSTLK | 
    250:
    EVLDNLDSHL | KRSEYFRFLW | FPHTENVSII | YQDHTNKAPS | SASNWFWDYA | 
    300:
    IGFYLLEFLL | WTSTYLPCLV | GWINRFFFWM | LFNCKKESSN | LSHKIFTYEC | 
    350:
    RFKQHVQDWA | IPREKTKEAL | LELKAMLEAH | PKVVAHYPVE | VRFTRGDDIL | 
    400:
    LSPCFQRDSC | YMNIIMYRPY | GKDVPRLDYW | LAYETIMKKF | GGRPHWAKAH | 
    440:
    NCTQKDFEEM | YPTFHKFCDI | REKLDPTGMF | LNSYLEKVFY | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat LGO
    Cat.:
    E15352m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat LGO
    Cat.:
    E15352b
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat LGO
    Cat.:
    E15352p
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    96T
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    ELISA Kit for Rat LGO
    Cat.:
    E15352r
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    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Rat LGO
    Cat.:
    U15352r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat LGO
    Cat.:
    U15352m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat LGO
    Cat.:
    U15352b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat LGO
    Cat.:
    U15352p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat LGO
    Cat.:
    P15352Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat LGO
    Polyclonal Antibody for Rat LGO
    Cat.:
    P15352Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat LGO
    Monoclonal Antibody for Rat LGO
    Monoclonal Antibody for Rat LGO
    Monoclonal Antibody for Rat LGO
    Monoclonal Antibody for Rat LGO
    Protein for Rat LGO
    Protein for Rat LGO
    Protein for Rat LGO
    Protein for Rat LGO

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    References
    1. 1.
      "Isolation and sequence analysis of a complementary DNA encoding rat liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis."
      Koshizaka T. , Nishikimi M. , Ozawa T. , Yagi K.
      J. Biol. Chem.263:1619-1621(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PARTIAL PROTEIN SEQUENCE
    2. 2.
      "Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species."
      Nishikimi M. , Kawai T. , Yagi K.
      J. Biol. Chem.267:21967-21972(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: Sprague-Dawley.
      tissue: Liver.
    3. 3.
      "Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis."
      Nishikimi M. , Yagi K.
      Am. J. Clin. Nutr.54:1203S-1208S(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    5. 5.
      "Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase."
      Nishikimi M. , Koshizaka T. , Ozawa T. , Yagi K.
      Arch. Biochem. Biophys.267:842-846(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-237
    6. 6.
      "L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver."
      Fujitsuka N. , Yokozawa T. , Oura H. , Akao T. , Kobashi K. , Ienaga K. , Nakamura K.
      Nephron63:445-451(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-41;FUNCTION
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